A thriller set in Benares, Jaipur, Mumbai and Delhi, Setters is about a racket profiteering from academic scams. The film follows a cat-and-mouse game between two good friends: one a cop, and the other a "setter" who arranges brilliant students in place of weak students to appear in examinations.

A man (R. Madhavan) who helps wronged parties get out of bad relationships meets his match when he takes on a business partner (Bipasha Basu).