In a wacky Rhode Island town, a dysfunctional family strives to cope with everyday life as they are thrown from one crazy scenario to another.

The series focuses on an eccentric motley crew that is the Smith family and their three housemates: Father, husband, and breadwinner Stan Smith; his better half housewife, Francine Smith; their college-aged daughter, Hayley Smith; and their high-school-aged son, Steve Smith. Outside of the Smith family, there are three additional main characters, including Hayley's boyfriend turned husband, Jeff Fischer; the family's man-in-a-goldfish-body pet, Klaus; and most notably the family's zany alien, Roger, who is "full of masquerades, brazenness, and shocking antics."

Follow the iconic cat and mouse duo as they settle in to their new digs at the Royal Gate Hotel and unleash mayhem across the big city, inciting hilarious chaos uptown, downtown and everywhere their manic escapades take them.

Always up to their old shenanigans, Tom and Jerry solve crimes as detectives, bedevil witches Beatie and Hildie, and forever torment each other.