Sarangapani, a man who finds comfort in the guidance of horoscopes, sets off on a turbulent journey that forces him to confront some hard truths about himself and his life.

During a Ganesh Chaturthi celebration, small-time thief Ganesh attempts a major heist that goes awry, leading to a comical clash with Rudra and his boss Kishore Reddy, who are also searching for a valuable item amidst the festive chaos.

Follows three characters from diverse backgrounds in their mid twenties. How consequences arise because of their flaws and what struggles they go through?

Thaggede Le story is about a murder investigation that revolves around nabbing of a drug lord. SI Chalapathy (Ravi Shankar) and his subordinate Raja (Raja Raveendra) bring Easwar (Naveen Chandra) , a software engineer to a Daba and start interrogating him over a murder case. Even as they are busy with their interrogation, the drug mafia is furious with the missing cartel and the dreaded Dandupalyam gang comprising gang leader Krishna (Makarand Desh Pande), Lakshmi (Pooja Gandhi), Chander (Ravi Kale), and others escape. Where this leads to and what is the connection to the murder mystery and how they are related to Eswar's wife Devi (Divya Pillai), Lizy (Ananaya SenGupta) form the crux of Thaggede Le.

Santhosh, a youth who is struggling with 'Micro Penis Syndrome' marries Amrutha in an unavoidable situation but continues to postpone their first night nuptials. He comes across a Godwoman who has a herbal medicine to address his problem.